Structural and Functional Disparities within the Human Gut Virome in Terms of Genome Topology and Representative Genome Selection.

ABSTRACT: Circularity confers protection to viral genomes where linearity falls short, thereby fulfilling the form follows function aphorism. However, a shift away from morphology-based classification toward the molecular and ecological classification of viruses is currently underway within the field of virology. Recent years have seen drastic changes in the International Committee on Taxonomy of Viruses' operational definitions of viruses, particularly for the tailed phages that inhabit the human gut. After the abolition of the order Caudovirales, these tailed phages are best defined as members of the class Caudoviricetes. To determine the epistemological value of genome topology in the context of the human gut virome, we designed a set of seven experiments to assay the impact of genome topo

SUBMITTER: Veldsman WP 

PROVIDER: S-EPMC10820185 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature