Development of Fluorescent Chemosensors for Calcium and Lead Detection.

ABSTRACT: In the present work, several coumarin-3-carboxamides with different azacrown ether moieties were designed and tested as potential luminescent sensors for metal ions. The derivative containing a 1-aza-15-crown-5 as a metal chelating group was found to yield the strongest response for Ca²⁺ and Pb²⁺, exhibiting an eight- and nine-fold emission increase, respectively, while other cations induced no changes in the optical properties of the chemosensor molecule. Job's plots revealed a 1:1 binding stoichiometry, with association constants of 4.8 × 10⁴ and 8.7 × 10⁴ M^-1, and limits of detection of 1.21 and 8.04 µM, for Ca²⁺ and Pb²⁺, respectively. Computational studies suggest the existence of a PET quenching mechanism, w

SUBMITTER: Gomes LJ 

PROVIDER: S-EPMC10820191 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature