Mitochondrial Melatonin: Beneficial Effects in Protecting against Heart Failure.

ABSTRACT: Cardiovascular disease is the cause of physical infirmity and thousands of deaths annually. Typically, during heart failure, cardiomyocyte mitochondria falter in terms of energy production and metabolic processing. Additionally, inflammation and the accumulation of non-contractile fibrous tissue contribute to cardiac malfunction. Melatonin, an endogenously produced molecule, experimentally reduces the initiation and progression of atherosclerotic lesions, which are often the basis of coronary artery disease. The current review critically analyzes published data related to the experimental use of melatonin to forestall coronary artery pathologies. Collectively, these studies document melatonin's anti-atherosclerotic actions in reducing LDL oxidation and triglyceride levels, lowering endothe

SUBMITTER: Reiter RJ 

PROVIDER: S-EPMC10820220 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature