Palatability and Stability Studies to Optimize a Carvedilol Oral Liquid Formulation for Pediatric Use.

ABSTRACT: Carvedilol (CARV) is a blocker of α- and β- adrenergic receptors, used as an "off-label" treatment for cardiovascular diseases in pediatrics. Currently, there is no marketed pediatric-appropriate CARV liquid formulation, so its development is necessary. Palatability (appreciation of smell, taste, and aftertaste) is a key aspect to be considered during the development of pediatric formulations since only formulations with good palatability also have adequate acceptability in this population. Consequently, the aim of this research was to assess the palatability and acceptability of different CARV formulations using an in vivo taste assessment (ID Number PR103/22) in order to select the highest palatability-rated CARV formulation. The preparation of CARV formulations was based on a reference

SUBMITTER: Chiclana-Rodriguez B 

PROVIDER: S-EPMC10820228 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature