Effectiveness of next-generation sequencing for patients with advanced non-small-cell lung cancer: a population-based registry study.

ABSTRACT:

Background

Despite the growing use of next-generation sequencing (NGS) in the management of advanced non-small-cell lung cancer (NSCLC), there is little evidence that its use leads to improved clinical outcomes. This study aimed to compare the effectiveness of NGS with that of single-gene testing (SGT) alone in patients with advanced NSCLC.

Materials and methods

This was a retrospective cohort study conducted on patients diagnosed with advanced lung adenocarcinoma between 2017 and 2018 from a nationwide, population-based database. We identified patients who had SGT exclusively (SGT group) or underwent upfront NGS or NGS following SGT as an initial evaluation (NGS group). Patients were followed up until death or the end of the study (31 December 2019). The adjusted hazard rat

SUBMITTER: Kang DW 

PROVIDER: S-EPMC10820286 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature