COL11A1 is associated with developmental dysplasia of the hip and secondary osteoarthritis in the HUNT study.

ABSTRACT:

Objective

Developmental dysplasia of the hip (DDH) is a congenital condition affecting 2-3% of all infants. DDH increases the risk of osteoarthritis, is the cause of 30 ​% of all total hip arthroplasties (THAs) in adults <40 years of age and can result in loss of life quality. Our aim was to explore the genetic background of DDH in order to improve diagnosis, management and longterm outcome.

Design

We used the large, ongoing, longitudinal Trøndelag Health Study (HUNT) database. Case definition was based on ICD-9/-10 diagnoses of DDH, or osteoarthritis secondary to DDH. Analyses were performed using SAIGE software, with covariates including sex, batch, birth year and principal components. We included only single nucleotide polymorphisms (SNPs) with minor allele frequency (MAF

SUBMITTER: Jacobsen KK 

PROVIDER: S-EPMC10820335 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature