Polyethylene Terephthalate Hydrolases in Human Gut Microbiota and Their Implications for Human Health.

ABSTRACT: Polyethylene terephthalate (PET), primarily utilized for food and beverage packaging, consistently finds its way into the human gut, thereby exerting adverse effects on human health. PET hydrolases, critical for the degradation of PET, have been predominantly sourced from environmental microbial communities. Given the fact that the human gut harbors a vast and intricate consortium of microorganisms, inquiry into the presence of potential PET hydrolases within the human gut microbiota becomes imperative. In this investigation, we meticulously screened 22,156 homologous sequences that could potentially encode PET hydrolases using the hidden Markov model (HMM) paradigm, drawing from 4984 cultivated genomes of healthy human gut bacteria. Subsequently, we methodically validated the hydrolytic e

SUBMITTER: Zhou H 

PROVIDER: S-EPMC10820491 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature