Increased Efficiency of a Functional SOD Mimic Achieved with Pyridine Modification on a Pyclen-Based Copper(II) Complex.

ABSTRACT: A series of Cu(II) complexes with the formula [Cu^RPyN₃]²⁺ varying in substitution on the pyridine ring were investigated as superoxide dismutase (SOD) mimics to identify the most efficient reaction rates produced by a synthetic, water-soluble copper-based SOD mimic reported to date. The resulting Cu(II) complexes were characterized by X-ray diffraction analysis, UV-visible spectroscopy, cyclic voltammetry, and metal-binding (log β) affinities. Unique to this approach, the modifications to the pyridine ring of the PyN₃ parent system tune the redox potential while exhibiting high binding stabilities without changing the coordination environment of the metal complex within the PyN

SUBMITTER: Mekhail MA 

PROVIDER: S-EPMC10820499 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature