Paclitaxel and Therapeutic Drug Monitoring with Microsampling in Clinical Practice.

ABSTRACT: Paclitaxel is an anticancer agent efficacious in various tumors. There is large interindividual variability in drug plasma concentrations resulting in a wide variability in observed toxicity in patients. Studies have shown the time the concentration of paclitaxel exceeds 0.05 µM is a predictive parameter of toxicity, making dose individualization potentially useful in reducing the adverse effects. To determine paclitaxel drug concentration, a venous blood sample collected 24 h following the end of infusion is required, often inconvenient for patients. Alternatively, using a microsampling device for self-sampling would facilitate paclitaxel monitoring regardless of the patient's location. We investigated the feasibility of collecting venous and capillary samples (using a Mitra^® d

SUBMITTER: Radovanovic M 

PROVIDER: S-EPMC10820540 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature