Predictors of Breakthrough SARS-CoV-2 Infection after Vaccination.

ABSTRACT: The initial two-dose vaccine series and subsequent booster vaccine doses have been effective in modulating SARS-CoV-2 disease severity and death but do not completely prevent infection. The correlates of infection despite vaccination continue to be under investigation. In this prospective decentralized study (n = 1286) comparing antibody responses in an older- (≥70 years) to a younger-aged cohort (aged 30-50 years), we explored the correlates of breakthrough infection in 983 eligible subjects. Participants self-reported data on initial vaccine series, subsequent booster doses and COVID-19 infections in an online portal and provided self-collected dried blood spots for antibody testing by ELISA. Multivariable survival analysis explored the correlates of breakthrough infection. An associatio

SUBMITTER: Walmsley S 

PROVIDER: S-EPMC10820583 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature