The Impact of Various Poly(vinylpyrrolidone) Polymers on the Crystallization Process of Metronidazole.

ABSTRACT: In this paper, we propose one-step synthetic strategies for obtaining well-defined linear and star-shaped polyvinylpyrrolidone (linPVP and starPVP). The produced macromolecules and a commercial PVP K30 with linear topology were investigated as potential matrices for suppressing metronidazole (MTZ) crystallization. Interestingly, during the formation of binary mixtures (BMs) containing different polymers and MTZ, we found that linear PVPs exhibit maximum miscibility with the drug at a 50:50 weight ratio (w/w), while the star-shaped polymer mixes with MTZ even at a 30:70 w/w. To explain these observations, comprehensive studies of MTZ-PVP formulations with various contents of both components were performed using Fourier-transform infrared spectroscop

SUBMITTER: Orszulak L 

PROVIDER: S-EPMC10820696 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature