Mutation of p53 increases the competitive ability of pluripotent stem cells.

ABSTRACT: During development, the rate of tissue growth is determined by the relative balance of cell division and cell death. Cell competition is a fitness quality-control mechanism that contributes to this balance by eliminating viable cells that are less fit than their neighbours. The mutations that confer cells with a competitive advantage and the dynamics of the interactions between winner and loser cells are not well understood. Here, we show that embryonic cells lacking the tumour suppressor p53 are 'super-competitors' that eliminate their wild-type neighbours through the direct induction of apoptosis. This elimination is context dependent, as it does not occur when cells are pluripotent and it is triggered by the onset of differentiation. Furthermore, by combining mathematical modelling and

SUBMITTER: Perez Montero S 

PROVIDER: S-EPMC10820806 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature