Organogenetic transcriptomes of the Drosophila embryo at single cell resolution.

ABSTRACT: To gain insight into the transcription programs activated during the formation of Drosophila larval structures, we carried out single cell RNA sequencing during two periods of Drosophila embryogenesis: stages 10-12, when most organs are first specified and initiate morphological and physiological specialization; and stages 13-16, when organs achieve their final mature architectures and begin to function. Our data confirm previous findings with regards to functional specialization of some organs - the salivary gland and trachea - and clarify the embryonic functions of another - the plasmatocytes. We also identify two early developmental trajectories in germ cells and uncover a potential role for proteolysis during germline stem cell specialization. We identify the likely cell type of origin

SUBMITTER: Peng D 

PROVIDER: S-EPMC10820837 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature