Sensory nerve regulates progenitor cells via FGF-SHH axis in tooth root morphogenesis.

ABSTRACT: Nerves play important roles in organ development and tissue homeostasis. Stem/progenitor cells differentiate into different cell lineages responsible for building the craniofacial organs. The mechanism by which nerves regulate stem/progenitor cell behavior in organ morphogenesis has not yet been comprehensively explored. Here, we use tooth root development in mouse as a model to investigate how sensory nerves regulate organogenesis. We show that sensory nerve fibers are enriched in the dental papilla at the initiation of tooth root development. Through single cell RNA-sequencing analysis of the trigeminal ganglion and developing molar, we reveal several signaling pathways that connect the sensory nerve with the developing molar, of which FGF signaling appears to be one of the important reg

SUBMITTER: Pei F 

PROVIDER: S-EPMC10820866 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature