Snake Venom: A Promising Source of Neurotoxins Targeting Voltage-Gated Potassium Channels.

ABSTRACT: The venom derived from various sources of snakes represents a vast collection of predominantly protein-based toxins that exhibit a wide range of biological actions, including but not limited to inflammation, pain, cytotoxicity, cardiotoxicity, and neurotoxicity. The venom of a particular snake species is composed of several toxins, while the venoms of around 600 venomous snake species collectively encompass a substantial reservoir of pharmacologically intriguing compounds. Despite extensive research efforts, a significant portion of snake venoms remains uncharacterized. Recent findings have demonstrated the potential application of neurotoxins derived from snake venom in selectively targeting voltage-gated potassium channels (Kv). These neurotoxins include BPTI-Kunitz polypeptides, PLA

SUBMITTER: AlShammari AK 

PROVIDER: S-EPMC10820993 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature