P66ShcA promotes malignant breast cancer phenotypes by alleviating energetic and oxidative stress.

ABSTRACT: Significant efforts have focused on identifying targetable genetic drivers that support the growth of solid tumors and/or increase metastatic ability. During tumor development and progression to metastatic disease, physiological and pharmacological selective pressures influence parallel adaptive strategies within cancer cell sub-populations. Such adaptations allow cancer cells to withstand these stressful microenvironments. This Darwinian model of stress adaptation often prevents durable clinical responses and influences the emergence of aggressive cancers with increased metastatic fitness. However, the mechanisms contributing to such adaptive stress responses are poorly understood. We now demonstrate that the p66ShcA redox protein, itself a ROS inducer, is essential for survival in respon

SUBMITTER: Lewis K 

PROVIDER: S-EPMC10821068 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature