Improved Olfactory Deposition of Theophylline Using a Nanotech Soft Mist Nozzle Chip.

ABSTRACT: Currently, nasal administration of active pharmaceutical ingredients is most commonly performed using swirl-nozzle-based pump devices or pressurized syringes. However, they lead to limited deposition in the more active regions of the nasal cavity, especially the olfactory region, which is crucial for nose-to-brain drug delivery. This research proposes to improve deposition in the olfactory region by replacing the swirl nozzle with a nanoengineered nozzle chip containing micrometer-sized holes, which generates smaller droplets of 10-50 μm travelling at a lower plume velocity. Two nanotech nozzle chips with different hole sizes were tested at different inhalation flow rates to examine the deposition patterns of theophylline, a hyposmia treatment formulation, using a nasal cavity model. A use

SUBMITTER: Zhang MX 

PROVIDER: S-EPMC10821129 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature