Breast cancer cells have an increased ferroptosis risk induced by system x_c^- blockade after deliberately downregulating CYTL1 to mediate malignancy.

ABSTRACT: Cytokine-like protein 1 (CYTL1) expression is deliberately downregulated during the progression of multiple types of cancers, especially breast cancer. However, the metabolic characteristics of cancer progression remain unclear. Here, we uncovered a risk of breast cancer cells harboring low CYTL1 expression, which is metabolically controlled during malignant progression. We performed metabolism comparison and revealed that breast cancer cells with low CYTL1 expression have highly suppressed transsulfuration activity that is driven by cystathionine β-synthase (CBS) and contributes to de novo cysteine synthesis. Mechanistically, CYTL1 activated Nrf2 by promoting autophagic Keap1 degradation, and Nrf2 subsequently transactivated CBS expression. Due to the lack of cellular cysteine synthesis,

SUBMITTER: Xue W 

PROVIDER: S-EPMC10821163 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature