Integrative HLA typing of tumor and adjacent normal tissue can reveal insights into the tumor immune response.

ABSTRACT:

Background

The HLA complex is the most polymorphic region of the human genome, and its improved characterization can help us understand the genetics of human disease as well as the interplay between cancer and the immune system. The main function of HLA genes is to recognize "non-self" antigens and to present them on the cell surface to T cells, which instigate an immune response toward infected or transformed cells. While sequence variation in the antigen-binding groove of HLA may modulate the repertoire of immunogenic antigens presented to T cells, alterations in HLA expression can significantly influence the immune response to pathogens and cancer.

Methods

RNA sequencing was used here to accurately genotype the HLA region and quantify and compare the level of allele-speci

SUBMITTER: Sverchkova A 

PROVIDER: S-EPMC10821267 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature