Trace Metal Impurities Effects on the Formation of [⁶⁴Cu]Cu-diacetyl-bis(N⁴-methylthiosemicarbazone) ([⁶⁴Cu]Cu-ATSM).

ABSTRACT: [⁶⁴Cu]Cu-diacetyl-bis(N⁴-methylthiosemicarbazone) ([⁶⁴Cu]Cu-ATSM) is a radioactive hypoxia-targeting therapeutic agent being investigated in clinical trials for malignant brain tumors. For the quality management of [⁶⁴Cu]Cu-ATSM, understanding trace metal impurities' effects on the chelate formation of ⁶⁴Cu and ATSM is important. In this study, we conducted coordination chemistry studies on metal-ATSM complexes. First, the effects of nonradioactive metal ions (Cu²⁺, Ni²⁺, Zn²⁺, and Fe²⁺) on the formation of [⁶⁴Cu]Cu-ATSM were evaluated. When the amount of Cu²⁺ or Ni²⁺ added was 1.2 mol or 288 mol, equivalent to ATSM, the labeling yield of [⁶⁴

SUBMITTER: Shinada M 

PROVIDER: S-EPMC10821298 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature