The Cytotoxic Effects of Fine Particulate Matter (PM_2.5) from Different Sources at the Air-Liquid Interface Exposure on A549 Cells.

ABSTRACT: The health of humans has been negatively impacted by PM_2.5 exposure, but the chemical composition and toxicity of PM_2.5 might vary depending on its source. To investigate the toxic effects of particulate matter from different sources on lung epithelial cells (A549), PM_2.5 samples were collected from residential, industrial, and transportation areas in Nanjing, China. The chemical composition of PM_2.5 was analyzed, and toxicological experiments were conducted. The A549 cells were exposed using an air-liquid interface (ALI) exposure system, and the cytotoxic indicators of the cells were detected. The research results indicated that acute exposure to different sources of particulate matter at the air-liquid interface caused damage to the cells, indu

SUBMITTER: Yan Z 

PROVIDER: S-EPMC10821317 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature