Critical limb-threatening ischaemia and microvascular transformation: clinical implications.

ABSTRACT:

Background and aims

Clinical management of critical limb-threatening ischaemia (CLTI) is focused on prevention and treatment of atherosclerotic arterial occlusions. The role of microvascular pathology in disease progression is still largely unspecified and more importantly not utilized for treatment. The aim of this explorative study was to characterize the role of the microvasculature in CLTI pathology.

Methods

Clinical high-resolution imaging of CLTI patients (n = 50) and muscle samples from amputated CLTI limbs (n = 40) were used to describe microvascular pathology of CLTI at the level of resting muscle blood flow and microvascular structure, respectively. Furthermore, a chronic, low arterial driving pressure-simulating ischaemia model in rabbits (n = 24) was used togethe

SUBMITTER: Tarvainen S 

PROVIDER: S-EPMC10821383 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature