Microwave-Promoted Total Synthesis of Puniceloid D for Modulating the Liver X Receptor.

ABSTRACT: A growing global health concern is metabolic syndrome, which is defined by low HDL, diabetes, hypertension, and abdominal obesity. Nuclear receptors are attractive targets for treatment of diseases associated with metabolic syndrome. Liver X receptors (LXRs) have become one of the most significant pharmacological targets among nuclear receptors. Multiple research studies emphasize the essential function of the liver X receptor (LXR) in the pathophysiology of metabolic syndrome. Puniceloid D, among natural products, demonstrated promising effects on LXRα. However, attempts at the total synthesis of natural products were faced with challenges, including long synthetic steps and low yields, requiring a more efficient approach. In this study, for the first time, we successfully synthesized pun

SUBMITTER: Jung YJ 

PROVIDER: S-EPMC10821398 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature