Gut Biogeography Accentuates Sex-Related Differences in the Murine Microbiome.

ABSTRACT: Recent studies have highlighted the influence of factors such as sex and sex-linked hormones on microbiome composition, raising concerns about the generalizability of findings. Here, we explore whether gut geography, specifically the upper and lower gastrointestinal tract (GI), contributes to sex-linked microbiome differences in mice. We collected microbial samples throughout the length of the GI from male and female C57B6/J mice at 6- and 8-weeks old, and conducted 16S rRNA sequencing. Our findings revealed significant sex-related differences, with Clostridium_sensu_stricto_1 more abundant in the male colon, while females exhibited higher levels of Dubosiella newyorkensis across all organs at 6 weeks. We also observed decreased Shannon alpha diversity in the small intestine

SUBMITTER: Ortiz-Alvarez de la Campa M 

PROVIDER: S-EPMC10821414 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature