Association of Maternal Age and Blood Markers for Metabolic Disease in Newborns.

ABSTRACT: Pregnancy at an advanced maternal age is considered a risk factor for adverse maternal, fetal, and neonatal outcomes. Here we investigated whether maternal age could be associated with differences in the blood levels of newborn screening (NBS) markers for inborn metabolic disorders on the Recommended Universal Screening Panel (RUSP). Population-level NBS data from screen-negative singleton infants were examined, which included blood metabolic markers and covariates such as age at blood collection, birth weight, gestational age, infant sex, parent-reported ethnicity, and maternal age at delivery. Marker levels were compared between maternal age groups (age range: 1544 years) using effect size analyses, which controlled for differences in group sizes and potential confounding from other cova

SUBMITTER: Xie Y 

PROVIDER: S-EPMC10821442 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature