Proteomics Applications in <i>Toxoplasma gondii</i>: Unveiling the Host-Parasite Interactions and Therapeutic Target Discovery.

ABSTRACT: Toxoplasma gondii, a protozoan parasite with the ability to infect various warm-blooded vertebrates, including humans, is the causative agent of toxoplasmosis. This infection poses significant risks, leading to severe complications in immunocompromised individuals and potentially affecting the fetus through congenital transmission. A comprehensive understanding of the intricate molecular interactions between T. gondii and its host is pivotal for the development of effective therapeutic strategies. This review emphasizes the crucial role of proteomics in T. gondii research, with a specific focus on host-parasite interactions, post-translational modifications (PTMs), PTM crosstalk, and ongoing efforts in drug discovery. Additionally, we provide an overview of recent adva

SUBMITTER: Deng B 

PROVIDER: S-EPMC10821451 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature