Microbial-Dependent Recruitment of Immature Myeloid Cells Promotes Intestinal Regeneration.

ABSTRACT:

Background & aims

The intestinal epithelium functions both in nutrient absorption and as a barrier, separating the luminal contents from a network of vascular, fibroblastic, and immune cells underneath. After injury to the intestine, multiple cell populations cooperate to drive regeneration of the mucosal barrier, including lymphatic endothelial cells (LECs). A population of granulocytic immature myeloid cells (IMCs), marked by Hdc, participate in regeneration of multiple organs such as the colon and central nervous system, and their contribution to intestinal regeneration was investigated.

Methods

By using male and female histidine decarboxylase (Hdc) green fluorescent reporter (GFP) mice, we investigated the role of Hdc⁺ IMCs in intestinal regeneration after exp

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC10821484 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature