Rate of pachymeningeal failure following adjuvant WBRT vs SRS in patients with brain metastases.

ABSTRACT:

Background

Stereotactic radiosurgery (SRS) has supplanted whole brain radiotherapy (WBRT) as standard-of-care adjuvant treatment following surgery for brain metastasis (BrM). Concomitant with the adoption of adjuvant SRS, a new pattern of failure termed "Pachymeningeal failure" (PMF) has emerged.

Methods

We reviewed a prospective registry of 264 BrM patients; 145 and 119 were treated adjuvantly with WBRT and SRS, respectively. The Cox proportional hazards model was used to identify variables correlating to outcomes. Outcomes were calculated using the cumulative incidence (CI) method. Univariate (UVA) and multivariate analyses (MVA) were done to identify factors associated with PMF.

Results

CI of PMF was 2 % and 18 % at 12 months, and 2 % and 23 % at 24 months for WRBT

SUBMITTER: Gutierrez-Valencia E 

PROVIDER: S-EPMC10821534 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature