Noninvasive serum N-glycans associated with ovarian cancer diagnosis and precancerous lesion prediction.

ABSTRACT:

Background

Ovarian cancer (OC) is one of the most common gynecological tumors with high morbidity and mortality. Altered serum N-glycome has been observed in many diseases, while the association between serum protein N-glycosylation and OC progression remains unclear, particularly for the onset of carcinogenesis from benign neoplasms to cancer.

Methods

Herein, a mass spectrometry based high-throughput technique was applied to characterize serum N-glycome profile in individuals with healthy controls, benign neoplasms and different stages of OC. To elucidate the alterations of glycan features in OC progression, an orthogonal strategy with lectin-based ELISA was performed.

Results

It was observed that the initiation and development of OC was associated with increased hig

SUBMITTER: Liu S 

PROVIDER: S-EPMC10821556 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature