A nonhuman primate model with Alzheimer's disease-like pathology induced by hippocampal overexpression of human tau.

ABSTRACT:

Background

Alzheimer's disease (AD) is one of the most burdening diseases of the century with no disease-modifying treatment at this time. Nonhuman primates (NHPs) share genetic, anatomical, and physiological similarities with humans, making them ideal model animals for investigating the pathogenesis of AD and potential therapies. However, the use of NHPs in AD research has been hindered by the paucity of AD monkey models due to their long generation time, ethical considerations, and technical challenges in genetically modifying monkeys.

Methods

Here, we developed an AD-like NHP model by overexpressing human tau in the bilateral hippocampi of adult rhesus macaque monkeys. We evaluated the pathological features of these monkeys with immunostaining, Nissl staining, cerebrospin

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC10821564 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature