No causal association between allergic rhinitis and migraine: a Mendelian randomization study.

ABSTRACT:

Purpose

Allergic rhinitis (AR) and migraine are among the most common public health problems worldwide. Observational studies on the correlation between AR and migraine have reported inconsistent results. This study aimed to investigate the causal relationship of AR with migraine and its subtypes, including migraine with aura (MA) and migraine without aura (MO).

Methods

Bidirectional two-sample Mendelian randomization (MR) analysis was performed with publicly available summary-level statistics of large genome-wide association studies to estimate the possible causal effects. The inverse variance-weighted method was selected for primary analysis and was supplemented with the weighted median, weighted mode, and MR-Egger methods. The causal analysis using summary effect estimate

SUBMITTER: Lv H 

PROVIDER: S-EPMC10821569 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature