Identification of brain endothelial cell-specific genes and pathways in ischemic stroke by integrated bioinformatical analysis.

ABSTRACT:

Background

Ischemic stroke (IS) is a life-threatening condition with limited treatment options; thus, finding the potential key genes for novel therapeutic targets is urgently needed. This study aimed to explore novel candidate genes and pathways of brain microvessel endothelial cells (ECs) in IS by bioinformatics analysis.

Materials and methods

The gene expression profiles of brain tissues or brain ECs in IS mice were downloaded from the online gene expression omnibus (GEO) to obtain the differentially expressed genes (DEGs) by R software. Functional enrichment analyses were used to cluster the functions and signaling pathways of the DEGs, while DEG-associated protein-protein interaction network was performed to identify hub genes. The target microRNAs and competitive endog

SUBMITTER: Yan Y 

PROVIDER: S-EPMC10821689 | biostudies-literature | 2023 Oct-Dec

REPOSITORIES: biostudies-literature