Integrin α3 promotes T_H17 cell polarization and extravasation during autoimmune neuroinflammation.

ABSTRACT: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) caused by CNS-infiltrating leukocytes, including T_H17 cells that are critical mediators of disease pathogenesis. Although targeting leukocyte trafficking is effective in treating autoimmunity, there are currently no therapeutic interventions that specifically block encephalitogenic T_H17 cell migration. Here, we report integrin α3 as a T_H17 cell-selective determinant of pathogenicity in experimental autoimmune encephalomyelitis. CNS-infiltrating T_H17 cells express high integrin α3, and its deletion in CD4⁺ T cells or Il17a fate-mapped cells attenuated disease severity. Mechanistically, integrin α3 enhanced the immunological synapse formation to p

SUBMITTER: Park E 

PROVIDER: S-EPMC10821720 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature