Tumor characteristics of dissociated response to immune checkpoint inhibition in advanced melanoma.

ABSTRACT:

Introduction

Immune checkpoint inhibition (ICI) has improved patients' outcomes in advanced melanoma, often resulting in durable response. However, not all patients have durable responses and the patients with dissociated response are a valuable subgroup to identify mechanisms of ICI resistance.

Methods

Stage IV melanoma patients treated with ICI and dissociated response were retrospectively screened for available samples containing sufficient tumor at least at two time-points. Included were one patient with metachronous regressive and progressive lesions at the same site, two patients with regressive and novel lesion at different sites, and three patients with regressive and progressive lesions at different sites. In addition, four patients with acquired resistant tumor sam

SUBMITTER: Versluis JM 

PROVIDER: S-EPMC10821835 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature