Tunable and Compartmentalized Multimaterial Bioprinting for Complex Living Tissue Constructs.

ABSTRACT: Recapitulating inherent heterogeneity and complex microarchitectures within confined print volumes for developing implantable constructs that could maintain their structure in vivo has remained challenging. Here, we present a combinational multimaterial and embedded bioprinting approach to fabricate complex tissue constructs that can be implanted postprinting and retain their three-dimensional (3D) shape in vivo. The microfluidics-based single nozzle printhead with computer-controlled pneumatic pressure valves enables laminar flow-based voxelation of up to seven individual bioinks with rapid switching between various bioinks that can solve alignment issues generated during switching multiple nozzles. To improve the spatial organization of various bioinks, printing fidelity wi

SUBMITTER: Hassan S 

PROVIDER: S-EPMC10822051 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature