The causal effect of reproductive factors on pelvic floor dysfunction: a Mendelian randomization study.

ABSTRACT:

Background

Pelvic floor dysfunction (PFD) is an extremely widespread urogynecologic disorder, the prevalence of which increases with aging. PFD has severely affected women's quality of life and has been called a social cancer. While previous studies have identified risk factors such as vaginal delivery and obesity for PFD, other reproductive factors, including age at menarche (AAMA), have been largely overlooked. Therefore, we used a Mendelian randomization (MR) study for the first time to investigate the potential causal relationship between reproductive factors and PFD.

Methods

We obtained summary statistics from genome-wide association studies (GWAS) for female genital prolapse (FGP), stress urinary incontinence (SUI), and five reproductive factors. Two-sample Mendelian r

SUBMITTER: Zhang S 

PROVIDER: S-EPMC10822177 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature