Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models.

ABSTRACT: Parkinson's disease (PD) is a neurodegenerative disorder characterized by nigrostriatal degeneration and the spreading of aggregated forms of the presynaptic protein α-synuclein (aSyn) throughout the brain. PD patients are currently only treated with symptomatic therapies, and strategies to slow or stop the progressive neurodegeneration underlying the disease's motor and cognitive symptoms are greatly needed. The time between the first neurobiochemical alterations and the initial presentation of symptoms is thought to span several years, and early neuroprotective dietary interventions could delay the disease onset or slow PD progression. In this study, we characterized the neuroprotective effects of isoflavones, a class of dietary polyphenols found in soy products and in the medicinal plan

SUBMITTER: de Rus Jacquet A 

PROVIDER: S-EPMC10822195 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature