Optimizer's dilemma: optimization strongly influences model selection in transcriptomic prediction.

ABSTRACT:

Motivation

Most models can be fit to data using various optimization approaches. While model choice is frequently reported in machine-learning-based research, optimizers are not often noted. We applied two different implementations of LASSO logistic regression implemented in Python's scikit-learn package, using two different optimization approaches (coordinate descent, implemented in the liblinear library, and stochastic gradient descent, or SGD), to predict mutation status and gene essentiality from gene expression across a variety of pan-cancer driver genes. For varying levels of regularization, we compared performance and model sparsity between optimizers.

Results

After model selection and tuning, we found that liblinear and SGD tended to perform comparably. liblinear mod

SUBMITTER: Crawford J 

PROVIDER: S-EPMC10822580 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature