Clostridioides difficile ferrosome organelles combat nutritional immunity.

ABSTRACT: Iron is indispensable for almost all forms of life but toxic at elevated levels^1-4. To survive within their hosts, bacterial pathogens have evolved iron uptake, storage and detoxification strategies to maintain iron homeostasis^1,5,6. Recent studies showed that three Gram-negative environmental anaerobes produce iron-containing ferrosome granules^7,8. However, it remains unclear whether ferrosomes are generated exclusively by Gram-negative bacteria. The Gram-positive bacterium Clostridioides difficile is the leading cause of nosocomial and antibiotic-associated infections in the USA⁹. Here we report that C. difficile undergoes an intracellular iron biomineralization process and stores iron in membrane-bound ferrosome organelles containing non-cryst

SUBMITTER: Pi H 

PROVIDER: S-EPMC10822667 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature