Recombinant antithrombin attenuates acute kidney injury associated with rhabdomyolysis: an in vivo animal study.

ABSTRACT:

Background

Rhabdomyolysis is characterized by the destruction and necrosis of skeletal muscle tissue, resulting in acute kidney injury (AKI). Recombinant antithrombin (rAT) has DNA repair and vascular endothelial-protection properties. Herein, we investigated whether rAT therapy has beneficial effects against rhabdomyolysis-induced AKI. Ten-week-old male B6 mice were injected with 5 mL/kg of 50% glycerol intramuscularly in the left thigh after 24 h of fasting to create a rhabdomyolysis mouse model. Further, 750 IU/kg rAT was injected intraperitoneally at 24 and 72 h after the rhabdomyolysis model was established. The mice were euthanized after 96 h for histological analysis. Saline was administered to mice in the control group.

Results

Blood tests show elevated serum creatin

SUBMITTER: Miura T 

PROVIDER: S-EPMC10822833 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature