Effect of time-dependent dialysate bicarbonate concentrations on acid-base and uremic solute kinetics during hemodialysis treatments.

ABSTRACT: Recent studies have suggested benefits for time-dependent dialysate bicarbonate concentrations (D_bic) during hemodialysis (HD). In this clinical trial, we compared for the first time in the same HD patients the effects of time-dependent changes with constant D_bic on acid-base and uremic solute kinetics. Blood acid-base and uremic solute concentration were measured in twenty chronic HD patients during 4-h treatments with A) constant D_bic of 35 mmol/L; B) D_bic of 35 mmol/L then 30 mmol/L; and C) D_bic of 30 mmol/L then 35 mmol/L (change of D_bic after two hours during Treatments B and C). Arterial blood samples were obtained predialysis, every hour during HD and one hour after HD, during second and third treatments of the week w

SUBMITTER: Wieliczko M 

PROVIDER: S-EPMC10822843 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature