Comprehensive analysis of miRNA profiling in Schistosoma mekongi across life cycle stages.

ABSTRACT: Schistosoma mekongi, a significant schistosome parasite, has various life stages, including egg, cercaria, female, and male, that play crucial roles in the complex life cycle. This study aimed to explore the microRNA (miRNA) profiles across these developmental stages to understand their potential functions and evolutionary significance, which have not been studied. Pre-processed sequencing reads of small RNA (sRNA) were obtained, and annotations were performed against the S. japonicum reference miRNA database. Results indicated marked variations in miRNA profiles across different life stages, with notable similarities observed between female and male S. mekongi. Principal Coordinate Analysis (PCoA) and unsupervised clustering revealed distinct miRNA signatures for each stage. Gene ontology

SUBMITTER: Sivapornnukul P 

PROVIDER: S-EPMC10822868 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature