Mitochondrial dynamics and metabolic regulation control T cell fate in the thymus.

ABSTRACT: Several studies demonstrated that mitochondrial dynamics and metabolic pathways control T cell fate in the periphery. However, little is known about their implication in thymocyte development. Our results showed that thymic progenitors (CD3^-CD4^-CD8^- triple negative, TN), in active division, have essentially a fused mitochondrial morphology and rely on high glycolysis and mitochondrial oxidative phosphorylation (OXPHOS). As TN cells differentiate to double positive (DP, CD4⁺CD8⁺) and single positive (SP, CD4⁺ and CD8⁺) stages, they became more quiescent, their mitochondria fragment and they downregulate glycolysis and OXPHOS. Accordingly, in vitro inhibition of the mitochondrial fission during progenitor dif

SUBMITTER: Elhage R 

PROVIDER: S-EPMC10822881 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature