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Recent advances in infectious disease research using cryo-electron tomography.

ABSTRACT: With the increasing spread of infectious diseases worldwide, there is an urgent need for novel strategies to combat them. Cryogenic sample electron microscopy (cryo-EM) techniques, particularly electron tomography (cryo-ET), have revolutionized the field of infectious disease research by enabling multiscale observation of biological structures in a near-native state. This review highlights the recent advances in infectious disease research using cryo-ET and discusses the potential of this structural biology technique to help discover mechanisms of infection in native environments and guiding in the right direction for future drug discovery.

SUBMITTER: Asarnow D

PROVIDER: S-EPMC10822977 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Recent advances in infectious disease research using cryo-electron tomography.

Asarnow Daniel D Becker Vada A VA Bobe Daija D Dubbledam Charlie C Johnston Jake D JD Kopylov Mykhailo M Lavoie Nathalie R NR Li Qiuye Q Mattingly Jacob M JM Mendez Joshua H JH Paraan Mohammadreza M Turner Jack J Upadhye Viraj V Walsh Richard M RM Gupta Meghna M Eng Edward T ET

Frontiers in molecular biosciences 20240115

With the increasing spread of infectious diseases worldwide, there is an urgent need for novel strategies to combat them. Cryogenic sample electron microscopy (cryo-EM) techniques, particularly electron tomography (cryo-ET), have revolutionized the field of infectious disease research by enabling multiscale observation of biological structures in a near-native state. This review highlights the recent advances in infectious disease research using cryo-ET and discusses the potential of this struct ...[more]

PMID: 38288336

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