Lipid nanoparticles: The game-changer in CRISPR-Cas9 genome editing.

ABSTRACT: The steady progress in genome editing, especially genome editing based on the use of clustered regularly interspaced short palindromic repeats (CRISPR) and programmable nucleases to make precise modifications to genetic material, has provided enormous opportunities to advance biomedical research and promote human health. However, limited transfection efficiency of CRISPR-Cas9 poses a substantial challenge, hindering its wide adoption for genetic modification. Recent advancements in nanoparticle technology, specifically lipid nanoparticles (LNPs), offer promising opportunities for targeted drug delivery. LNPs are becoming popular as a means of delivering therapeutics, including those based on nucleic acids and mRNA. Notably, certain LNPs, such as Polyethylene glycol-phospholipid-modified ca

SUBMITTER: Mohammadian Farsani A 

PROVIDER: S-EPMC10823087 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature