Effective prognostic risk model with cuproptosis-related genes in laryngeal cancer.

ABSTRACT:

Objective

Laryngeal cancer, characterized by high recurrence rates and a lack of effective biomarkers, has been associated with cuproptosis, a regulated cell death process linked to cancer progression. In this study, we aimed to explore the roles of cuproptosis-related genes in laryngeal cancer and their potential as prognostic markers and therapeutic targets.

Methods

We collected comprehensive data from The Cancer Genome Atlas and Gene Expression Omnibus databases, including gene expression profiles and clinical data of laryngeal cancer patients. Using clustering and gene analysis, we identified cuproptosis-related genes with prognostic significance. A risk model was constructed based on these genes, categorizing patients into high- and low-risk groups for outcome compariso

SUBMITTER: Li C 

PROVIDER: S-EPMC10823110 | biostudies-literature | 2024 Mar-Apr

REPOSITORIES: biostudies-literature