ST2-Mediated Neutrophilic Airway Inflammation: A Therapeutic Target for Patients With Uncontrolled Asthma.

ABSTRACT:

Purpose

Suppression of tumorigenicity 2 (ST2) has been proposed as the receptor contributing to neutrophilic inflammation in patients with type 2-low asthma. However, the exact role of ST2 in neutrophil activation remains poorly understood.

Methods

A total of 105 asthmatic patients (classified into 3 groups according to control status: the controlled asthma [CA], partly-controlled asthma [PA], and uncontrolled asthma [UA] groups), and 104 healthy controls were enrolled to compare serum levels of soluble ST2 (sST2) and interleukin (IL)-33. Moreover, the functions of ST2 in neutrophils and macrophages (Mϕ) were evaluated ex vivo and in vivo.

Results

Serum sST2 levels were significantly higher in the UA group than in the CA or PA groups (P < 0.05 for

SUBMITTER: Quoc QL 

PROVIDER: S-EPMC10823144 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature