Acute psychological stress-induced progenitor cell mobilization and cardiovascular events.

ABSTRACT:

Objective

Certain brain activation responses to psychological stress are associated with worse outcomes in CVD patients. We hypothesized that elevated acute psychological stress, manifesting as greater activity within neural centers for emotional regulation, mobilizes CPC from the bone marrow to the peripheral blood and predicts future cardiovascular events.

Methods

In 427 patients with stable CAD undergoing a laboratory-based mental stress (MS) test, CPCs were enumerated using flow cytometry as CD34-expressing mononuclear cells (CD34+) before and 45 min after stress. Changes in brain regional blood flow with MS were measured using high resolution-positron emission tomography (HR-PET). Association between the change in CPC with MS and the risk of cardiovascular death or myoc

SUBMITTER: Almuwaqqat Z 

PROVIDER: S-EPMC10823179 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature