Regulation of the innate immune response and gut microbiome by p53.

ABSTRACT: p53 is a key tumor suppressor mutated in half of human cancers. In recent years, p53 was shown to regulate a wide variety of functions. From the transcriptome analysis of 24 tissues of irradiated mice, we identified 553 genes markedly induced by p53. Gene Ontology (GO) enrichment analysis found that the most associated biological process was innate immunity. 16S rRNA-seq analysis revealed that Akkermansia, which has anti-inflammatory properties and is involved in the regulation of intestinal barrier integrity, was decreased in p53-knockout (p53^-/- ) mice after radiation. p53^-/- mice were susceptible to radiation-induced GI toxicity and had a significantly shorter survival time than p53-wild-type (p53^+/+ ) mice following radiation. However, administration of

SUBMITTER: Khor AHP 

PROVIDER: S-EPMC10823282 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature