Ubiquitin-specific protease 38 promotes inflammatory atrial fibrillation induced by pressure overload.

ABSTRACT:

Aims

Atrial structural and electrical remodelling is a major reason for the initiation and perpetuation of atrial fibrillation (AF). Ubiquitin-specific protease 38 (USP38) is a deubiquitinating enzyme, but its function in the heart remains unknown. The aim of this study was to investigate the effect of USP38 in pressure overload-induced AF.

Methods and results

Cardiac-specific knockout USP38 and cardiac-specific transgenic USP38 mice and their corresponding control mice were used in this study. After 4 weeks with or without aortic banding (AB) surgery, atrial echocardiography, atrial histology, electrophysiological study, and molecular analysis were assessed. Ubiquitin-specific protease 38 knockout mice showed a remarkable improvement in vulnerability to AF, atrial weight an

SUBMITTER: Xiao Z 

PROVIDER: S-EPMC10823351 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature